Skip Navigation LinksHome > November 2012 - Volume 31 - Issue 11 > Rash, Hepatotoxicity and Hyperbilirubinemia Among Kenyan Inf...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318267ef6a
HIV Reports

Rash, Hepatotoxicity and Hyperbilirubinemia Among Kenyan Infants Born to HIV-infected Women Receiving Triple-antiretroviral Drugs for the Prevention of Mother-to-child HIV Transmission

Minniear, Timothy D. MD*†; Zeh, Clement PhD†‡; Polle, Nicholas PhD§; Masaba, Rose MD; Peters, Philip J. MD; Oyaro, Boaz BS; Akoth, Benta MD; Ndivo, Richard MD; Angira, Frank MD; Mills, Lisa A. MD†‡; Thomas, Timothy K. MD†‡

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Abstract

We compared adverse events among breast-feeding neonates born to Kenyan mothers receiving triple-antiretroviral therapy, including either nevirapine or nelfinavir. Nevirapine-exposed infants had an absolute increase in the risk of rash but no significant risk differences for hepatotoxicity or high-risk hyperbilirubinemia compared with nelfinavir-exposed infants. From an infant-safety perspective, nevirapine-based regimens given during pregnancy and breast-feeding are viable options where alternatives to breast milk are not safe, affordable or feasible.

© 2012 Lippincott Williams & Wilkins, Inc.

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