Skip Navigation LinksHome > September 2012 - Volume 31 - Issue 9 > Impact of Six-week Viral Load on Mortality in HIV-infected Z...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318266aac2
HIV Reports

Impact of Six-week Viral Load on Mortality in HIV-infected Zimbabwean Infants

Mutasa, Kuda BSc*; Ntozini, Robert MPH*; Prendergast, Andrew DPhil*†‡; Iliff, Peter MRCPCH*; Rukobo, Sandra BSc*; Moulton, Lawrence H. PhD; Ward, Brian J. MD§; Humphrey, Jean H. ScD*†; the ZVITAMBO Study Group

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Abstract

Among 453 untreated HIV-infected Zimbabwean infants, 6-week viral load was the only infant factor that independently predicted mortality. Infants with viral load ≥ 1.59 million copies/mL (cohort median) had 3-fold increased mortality through 6 months (hazard ratio 3.07 [95% confidence interval: 2.16, 4.38]; P < 0.001) and 2-fold increased mortality through 12 months (hazard ratio 2.03 [95% confidence interval: 1.41, 2.91]; P < 0.001], compared with infants with viral load below the median.

© 2012 Lippincott Williams & Wilkins, Inc.

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