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Sudden Infant Death in an 8-Month-Old Baby With Dengue Virus Infection: Virus in Postmortem Tissues by Immunohistochemistry and Western Blotting

Neri, Margherita MD, PhD*; Othman, Shafie M. MD; Cantatore, Santina BS*; De Carlo, Dania MD*; Pomara, Cristoforo MD, PhD*; Riezzo, Irene MD, PhD*; Turillazzi, Emanuela MD, PhD*; Fineschi, Vittorio MD, PhD*

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31825c4a08
Brief Reports

Sudden infant death due to dengue virus infection is very rare. An 8-month-old male infant was found unresponsive during a nap in his nursery school. We emphasize the usefulness of dengue viral antigens as a postmortem diagnostic technique to demonstrate the presence of virus in human tissue specimens by immunohistochemistry and Western blotting.

Author Information

From the *Department of Forensic Pathology, University of Foggia, Ospedale Colonnello D’Avanzo, Foggia, Italy; and Forensic Department, Hospital Raja Permaisuri Bainun, Ipoh, Perak, Malaysia.

Accepted for publication April 21, 2012.

The authors have no conflicts of interest or funding to disclose.

Address for Correspondence: Vittorio Fineschi, MD, PhD, Department of Forensic Pathology, University of Foggia, Ospedale Colonnello D’Avanzo, Viale degli Aviatori 1, 71100 Foggia, Italy. E-mail:

© 2012 Lippincott Williams & Wilkins, Inc.