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Hearing Loss in Perinatally HIV-infected and HIV-exposed but Uninfected Children and Adolescents

Torre, Peter III PhD*; Zeldow, Bret MS; Hoffman, Howard J. MA; Buchanan, Ashley MS; Siberry, George K. MD§; Rice, Mabel PhD; Sirois, Patricia A. PhD; Williams, Paige L. PhD; for the Pediatric HIVAIDS Cohort Study

Pediatric Infectious Disease Journal: August 2012 - Volume 31 - Issue 8 - p 835–841
doi: 10.1097/INF.0b013e31825b9524
HIV Reports

Background: Little is known about hearing loss in children with HIV infection (HIV+). We examined the prevalence of hearing loss in perinatally HIV+ and HIV-exposed but uninfected (HEU) children, compared these with the percentage with hearing loss in the general population and evaluated possible risk factors for hearing loss in HIV+ and HEU children.

Methods: Audiometric examinations were completed in children who met any prespecified criteria for possible hearing loss. The hearing examination consisted of a tympanogram in each ear and pure-tone air-conduction threshold testing from 500 through 4000 Hz. Hearing loss was defined as the pure-tone average over these frequencies ≥20 dB hearing level. The associations of demographic variables, parent/caregiver, HIV disease and HIV treatment with hearing loss were evaluated with univariate and multivariable logistic regression models.

Results: Hearing testing was completed in 231 children (145 HIV+ and 86 HEU). Hearing loss occurred in 20.0% of HIV+ children and 10.5% of HEU children. After adjusting for caregiver education level, HIV infection was associated with increased odds of hearing loss (adjusted odds ratio = 2.13, 95% confidence interval: 0.95–4.76, P = 0.07). Among HIV+ children, those with a Centers for Disease Control and Prevention class C diagnosis had over twice the odds of hearing loss (adjusted odds ratio = 2.47, 95% confidence interval: 1.04–5.87, P = 0.04). The prevalence of hearing loss was higher in both HIV+ and HEU children compared with National Health and Nutrition Examination Survey III children.

Conclusions: Hearing loss was more common in both HIV+ and HEU children than in children from a US population sample. More advanced HIV illness increased the risk of hearing loss in HIV+ children.

From the *School of Speech, Language, and Hearing Sciences, San Diego State University, San Diego, CA; † Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA; ‡ Epidemiology and Statistics Program, National Institute on Deafness and Other Communication Disorders, Bethesda, MD; § Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD; ¶ Department of Speech-Language-Hearing: Sciences and Disorders, University of Kansas, Lawrence, KS; and ║ Tulane University School of Medicine, New Orleans, LA.

Accepted for publication April 20, 2012.

The Pediatric HIV/AIDS Cohort Study was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development with co-funding from the National Institute on Drug Abuse, the National Institute of Allergy and Infectious Diseases, the National Institute of Mental Health, the National Institute of Neurological Disorders and Stroke, the National Institute on Deafness and Other Communication Disorders, the National Heart Lung and Blood Institute and the National Institute on Alcohol Abuse and Alcoholism through cooperative agreements with the Harvard University School of Public Health (HD052102) (Principal Investigator: George Seage; Project Director: Julie Alperen) and the Tulane University School of Medicine (HD052104) (Principal Investigator: Russell Van Dyke; Co-Principal Investigator: Kenneth Rich; Project Director: Patrick Davis). Data management services were provided by Frontier Science and Technology Research Foundation (PI: Suzanne Siminski), and regulatory services and logistical support were provided by Westat, Inc (PI: Julie Davidson). The conclusions and opinions expressed in this article are those of the authors and do not necessarily reflect those of the National Institutes of Health or U.S. Department of Health and Human Services. The authors have no other conflicts of interest or funding to disclose.

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Address for Correspondence: Peter Torre, III, PhD, School of Speech, Language, and Hearing Sciences, San Diego State University, 5500 Campanile Dr., SLHS 244, San Diego, CA 92182-1518. E-mail: ptorre@mail.sdsu.edu.

© 2012 Lippincott Williams & Wilkins, Inc.