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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3182587796
HIV Reports

Survival Benefit of Early Infant Antiretroviral Therapy is Compromised When Diagnosis is Delayed

Wamalwa, Dalton MBChB, MPH, MMed Paed*; Benki-Nugent, Sarah MS, PhD; Langat, Agnes MBChB, MMed Paed*; Tapia, Ken MS; Ngugi, Evelyn MBChB*; Slyker, Jennifer A. PhD; Richardson, Barbra A. PhD§‡¶; John-Stewart, Grace C. MD, PhD

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Abstract

Late presentation is common among African HIV-1–infected infants. Incidence and correlates of mortality were examined in 99 infants with HIV-1 diagnosis by 5 months of age. Twelve-month survival was 66.8% (95% confidence interval: 55.9–75.6%). World Health Organization stage 3 or 4, underweight, wasting, microcephaly, low hemoglobin, pneumonia and gastroenteritis predicted mortality. Early HIV-1 diagnosis with antiretroviral therapy before symptomatic disease is critical for infant survival.

© 2012 Lippincott Williams & Wilkins, Inc.

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