Skip Navigation LinksHome > July 2012 - Volume 31 - Issue 7 > Bloodstream Infections During the First Year After Pediatric...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318256f9c3
Original Studies

Bloodstream Infections During the First Year After Pediatric Small Bowel Transplantation

Florescu, Diana F. MD*; Qiu, Fang MS, PhD; Langnas, Alan N. DO; Mercer, David F. MD; Chambers, Heather APRN*; Hill, Lisa A. APRN*; Qaragholi, Noor; Kalil, Andre C. MD, MPH*

Supplemental Author Material
Collapse Box


Background: Little information regarding bloodstream infections (BSIs) in small bowel transplantation has been published.

Methods: We reviewed the medical records of 98 pediatric patients who underwent small bowel transplantation. Patients’ characteristics were analyzed with Wilcoxon rank-sum, χ2 or Fisher’s exact tests. We estimated the overall survival by the Kaplan-Meier method and compared survival distributions between groups with the log-rank test.

Results: Sixty-eight patients developed ≥1episode of BSIs (total of 146 episodes), and 69.1% of the first infections were diagnosed in the 3 months post-transplantation. The most common sources of infection were as follows: central venous catheters (49.3%) and intra-abdominal infections (32.9%). Central venous catheters were present in 86.3%, and total parenteral nutrition within 7 days before infection was administered in 72.6% of episodes. Gram-positive bacteria (96 isolates) were more frequently isolated than Gram-negative bacteria (52 isolates), with Enterococcus spp. being the most commonly identified (48 isolates), followed by coagulase-negative Staphylococcus (40 isolates). Patients with infections were younger than those without (median 1.4 versus 2.1 years, P = 0.02). Four grafts were lost after transplantation in patients with BSIs and 2 in patients without BSIs (P = 0.99). One-year survival rate for patients without BSIs was 86.7% (95% confidence interval: 68.3%–94.8%) versus 72.1% in patients with BSIs (95% confidence interval: 59.8%–81.2%). Overall time to death was shorter in patients with BSIs than in patients without BSIs (P = 0.056).

Conclusions: Almost 70% of small bowel transplantation recipients developed BSIs, mainly in the early months after transplantation. BSIs were mainly from a central venous catheter or intra-abdominal source. Enterococcus spp were the most frequently isolated organisms. Patients with BSIs had worse survival than patients with BSIs.

© 2012 Lippincott Williams & Wilkins, Inc.


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.