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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318241d07e
HIV Reports

Total Lymphocyte Count as a Surrogate Marker to Predict CD4 Count in Human Immunodeficiency Virus-infected Children: A Retrospective Evaluation

Wang, Yuming PhD*,†; Li, Yuqian MM; Wang, Chongjian PhD*; Liang, Shuying MPH; Guo, Jinling PhD; Li, Zizhao MPH§; Zhang, Meixi MB*; Li, Wenjie PhD*

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Abstract

A retrospective study was conducted, and 576 human immunodeficiency virus–infected children with total lymphocyte count (TLC) and CD4 count were recruited from China. Spearman rank order correlation and receiver-operating characteristic were used. An overall positive correlation was noted between TLC and CD4 count (prehighly active antiretroviral therapy [pre-HAART], r = 0.789, 6 months of HAART, r = 0.642, 12 months of HAART, r = 0.691, P = 0.001). TLC ≤ 2600 cells/mm3 predicted a CD4 count of ≤350 cells/mm3 with 82.9% sensitivity, 79.6% specificity pre-HAART. Meanwhile, the optimum prediction for CD4 count of ≤350 cells/mm3 was a TLC of ≤2400 cells/mm3 at 6 months (73.6% sensitivity and 74.1% specificity) and 12 months (81.7% sensitivity and 76.5% specificity) of HAART. TLC can be used as a surrogate marker for predicting CD4 count of human immunodeficiency virus–infected children before and during HAART in resource-limited countries.

© 2012 Lippincott Williams & Wilkins, Inc.

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