Skip Navigation LinksHome > December 2011 - Volume 30 - Issue 12 > Increased Risk of Death in Human Immunodeficiency Virus-infe...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31822cca05
Pediatric HIV/AIDS

Increased Risk of Death in Human Immunodeficiency Virus-infected Children With Pneumococcal Meningitis in South Africa, 2003–2005

Nyasulu, Peter MSc (Med)*; Cohen, Cheryl FCP*,†; De Gouveia, Linda ND MT; Feldman, Charles DSc; Klugman, Keith P. PhD†,§,¶; von Gottberg, Anne FCP†,‖; for the Group for Enteric, Respiratory and Meningeal Diseases Surveillance in South Africa (GERMS-SA)

Supplemental Author Material
Collapse Box


Background: Pneumococcal disease is a major global cause of morbidity and mortality. This study evaluated risk factors for mortality in children with pneumococcal meningitis and other invasive pneumococcal diseases (IPD).

Methods: The study population included patients <15 years of age with laboratory-confirmed IPD and available outcome data between January 1, 2003 and December 31, 2005 as reported to a national laboratory-based surveillance program. Meningitis was defined by having pneumococcus identified from cerebrospinal fluid culture, while other IPD included patients with pneumococci identified from other normally sterile site specimens. Risk factors for mortality were evaluated using multivariable logistic regression.

Results: A total of 2251 patients with IPD were reported from sentinel sites: 581 with laboratory-confirmed meningitis and 1670 with other IPD. The case-fatality ratio was 35% (205/581) among meningitis cases and 18% (300/1670) among other IPD cases (P < 0.001). Among individuals with available human immunodeficiency virus (HIV) status data, HIV coinfection was less likely among patients with meningitis compared with other IPD (74% [244/328] vs. 82% [880/1067] P < 0.001). On multivariable analysis, HIV-infected status (odds ratio [OR]: 5.34, 95% confidence interval [CI]: 2.32–12.29), Pitt bacteremia score ≥4 (OR: 3.08, 95% CI: 1.21–7.83) and age group <1 year (OR: 2.58, 95% CI: 1.21–5.51) were independent predictors of death among patients with meningitis. Among children with other IPD, malnutrition was an independent predictor of death while HIV infection was not independently associated with increased risk of death.

Conclusions: Pneumococcal meningitis is associated with a high case-fatality ratio among South African children and this is increased by HIV coinfection. Increasing access to antiretroviral therapy and a catch-up program for pneumococcal conjugate vaccine among HIV-infected and malnourished children could reduce this excess mortality.

© 2011 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.