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Evolution of the Epidemiology of Pneumococcal Disease Among Utah Children Through the Vaccine Era

Ampofo, Krow MB ChB*; Pavia, Andrew T. MD*; Stockmann, Chris R. BSc*; Blaschke, Anne J. MD, PhD*; Weng, Hsin Yi Cindy MS*; Korgenski, Kent E. MS*,†; Daly, Judy PhD*,†; Byington, Carrie L. MD*

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318232ee3e
Brief Reports

From 1996 to 2009, we analyzed changes in pneumococcal disease (PD) in Utah children aged <18 years using International Classification of Diseases, ninth revision coded hospital discharges. We observed a sustained decrease in the incidence of PD among children <5 years in 2001–2004 (−36%) and 2005–2009 (−34%) compared with 1996–2000 (pre-7-valent pneumococcal conjugate vaccine). Decreases were primarily in bacteremia, uncomplicated pneumonia, and meningitis. In contrast, significant increases in complicated pneumonia/empyema were noted in children <5 years (+95% and +85%) and 5 to 17 years (+2% and +70%). Despite decreases in PD among Utah children, complicated pneumonia/empyema has increased during the 7-valent pneumococcal conjugate vaccine era.

Author Information

From the *Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, UT; and †Primary Children's Medical Center, Intermountain Health Care, Salt Lake City, UT.

Accepted for publication July 7, 2011.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Krow Ampofo, MB ChB, Division of Pediatric Infectious Diseases, University of Utah Health Sciences Center, 295 Chipeta Way, 2S010, Salt Lake City, UT 84108. E-mail:

© 2011 Lippincott Williams & Wilkins, Inc.