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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318224fb14
Online-Only: Original Studies

Persistence of Serum Bactericidal Antibody One Year After a Booster Dose of Either a Glycoconjugate or a Plain Polysaccharide Vaccine Against Serogroup C Neisseria meningitidis Given to Adolescents Previously Immunized With a Glycoconjugate Vaccine

de Whalley, Philip C. S. MA*; Snape, Matthew D. MD*; Kelly, Dominic F. PhD*; Banner, Carly MSc*; Lewis, Susan BSc*; Diggle, Linda PhD*; John, Tessa M. MA*; Yu, Ly-Mee MSc†; Omar, Omar MSc†; Borkowski, Astrid PhD‡; Pollard, Andrew J. PhD*

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Abstract

Background: Bactericidal antibody induced by immunization of infants with serogroup C Neisseria meningitidis (MenC) vaccines wanes rapidly during childhood. Adolescents are at particular risk from meningococcal disease, therefore they might benefit from a booster dose of vaccine. The duration of serologic response to such a booster in adolescents is unknown.

Methods: In a previous study, English schoolchildren, aged 9 to 12 years, who had received a monovalent MenC glycoconjugate vaccine in 1999–2000, were given either a plain polysaccharide vaccine (MenC-PS group, n = 150) or a glycoconjugate vaccine (MenC-CRM group, n = 95) at 13 to 15 years of age. In this follow-up study, serum bactericidal antibody titers and specific immunoglobulin G concentrations were assessed 1 year later. Results were compared with unboosted controls of similar age (control group, n = 298).

Results: Compliance with study protocol was achieved for 146 of the MenC-PS group, 92 of the MenC-CRM group, and 293 of the control group. Compared with the control group, both the MenC-PS and MenC-CRM groups had a significantly higher (P < 0.0001) geometric mean serum bactericidal antibody titers 1 year after the booster dose (geometric mean titers for MenC-PS group 3388 [95% confidence interval {CI}: 2460–4665]; MenC-CRM group 4417 [95% CI: 2951–6609]; control group 316 [95% CI: 252–396]). Specific immunoglobulin G concentration also rose and remained elevated 1 year after the booster.

Conclusions: A booster dose of MenC vaccine given to adolescents produced a marked rise in bactericidal antibody, which remained elevated 1 year later. Introduction of an adolescent booster of MenC vaccine might provide enhanced long-term population control of the disease.

© 2011 by Lippincott Williams & Wilkins, Inc.

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