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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3182272227
Brief Reports

Interferon-gamma Release Assay Performance for Diagnosing Tuberculosis Disease in 0- to 5-year-old Children

Debord, Camille PhD*; De Lauzanne, Agathe MD†; Gourgouillon, Nadège PhD*; Guérin-El Khourouj, Valérie PhD*; Pédron, Béatrice MD, PhD*; Gaudelus, Joel MD‡; Faye, Albert MD, PhD†; Sterkers, Ghislaine MD, PhD*

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Abstract

QuantiFERON-TB Gold In-Tube performance was evaluated in 19 French immunocompetent children (0.29–5.36 years; median: 1.52) with active tuberculosis. The rate of indeterminates results was 0/19 and the rates of positivity were 6/10 and 9/9 in <2 and 2- to 5-year-old children, respectively. QuantiFERON-TB Gold In-Tube in association with tuberculin skin test could improve diagnosis of tuberculosis even in young children.

© 2011 by Lippincott Williams & Wilkins, Inc.

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