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Interferon-gamma Release Assay Performance for Diagnosing Tuberculosis Disease in 0- to 5-year-old Children

Debord, Camille PhD*; De Lauzanne, Agathe MD†; Gourgouillon, Nadège PhD*; Guérin-El Khourouj, Valérie PhD*; Pédron, Béatrice MD, PhD*; Gaudelus, Joel MD‡; Faye, Albert MD, PhD†; Sterkers, Ghislaine MD, PhD*

Pediatric Infectious Disease Journal: November 2011 - Volume 30 - Issue 11 - pp 995-997
doi: 10.1097/INF.0b013e3182272227
Brief Reports

QuantiFERON-TB Gold In-Tube performance was evaluated in 19 French immunocompetent children (0.29–5.36 years; median: 1.52) with active tuberculosis. The rate of indeterminates results was 0/19 and the rates of positivity were 6/10 and 9/9 in <2 and 2- to 5-year-old children, respectively. QuantiFERON-TB Gold In-Tube in association with tuberculin skin test could improve diagnosis of tuberculosis even in young children.

From the *Laboratory of Immunology, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris 7 Denis Diderot University, Paris, France; †Department of Pediatrics, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris 7 Denis Diderot University, Paris, France; and ‡Department of Pediatrics, Jean Verdier Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bondy, France, Paris 13 University, Paris, France.

Accepted for publication May 31, 2011.

Partly supported by Assistance Publique - Hôpitaux de Paris.

The authors have no other funding or conflicts of interest to disclose.

A.D.L. and N.G. contributed equally to the work.

Reprints: Ghislaine Sterkers, MD, PhD, Hôpital Robert Debré- Laboratoire d'Immunologie, 48, Blvd Sérurier, 75019 Paris, France. E-mail: ghislaine.sterkers@rdb.aphp.fr.

© 2011 by Lippincott Williams & Wilkins, Inc.