Skip Navigation LinksHome > November 2011 - Volume 30 - Issue 11 > Absence Seizures Associated With Efavirenz Initiation
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318223b680
Brief Reports

Absence Seizures Associated With Efavirenz Initiation

Strehlau, Renate MB BCh*; Martens, Leigh MB BCh*; Coovadia, Ashraf MB BCh*; Dandara, Collet PhD†; Norman, Jennifer MSc‡; Maisel, Julia MB BCh*; Kuhn, Louise PhD§¶; Abrams, Elaine J. MD∥

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Abstract

Efavirenz, used in treating pediatric human immunodeficiency virus infection, has central nervous system side effects. We report on a 5-year-old girl with perinatally acquired human immunodeficiency virus infection, presenting with new onset absence seizures after starting treatment with efavirenz. Plasma efavirenz values were above therapeutic range. The child was homozygous for the CYP2B6–516T/T genotype, which is associated with poor efavirenz clearance. Seizures abated after efavirenz discontinuation.

© 2011 by Lippincott Williams & Wilkins, Inc.

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