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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31821ffe43
Brief Reports

Evidence of Homosubtypic But Not Heterosubtypic Immunity in Young Children Following Wild-type Influenza Illness

Ambrose, Christopher S. MD*; Wu, Xionghua PhD†

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Abstract

The effect of subtype-specific influenza illness in young children on the probability of influenza illness in the following year was analyzed for placebo recipients in four 2-year vaccine efficacy studies. There was evidence of homosubtypic protection but no evidence of heterosubtypic protection; however, a moderate-to-low level of heterosubtypic protection could not be ruled out. This analysis supports previous observations that children do not develop lasting, clinically significant heterosubtypic protection after influenza illness.

© 2011 Lippincott Williams & Wilkins, Inc.

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