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Dengue Antibody in Thai Children From Maternally Transferred Antibody to Acquired Infection

Pengsaa, Krisana MD*; Limkittikul, Kriengsak MD*; Yoksan, Sutee MD, PhD†; Wisetsing, Pataporn BED*; Sabchareon, Arunee MD*

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31821f07f6
Brief Reports
Abstract

This prospective cohort study examined serotype-specific neutralizing serum antibodies to dengue in 55 maternal-newborn pairs, at 3, 6, 9, 12, 18, and 24 months, and again at 4 to 8 years of age. In all, 95% of the mothers had neutralizing antibody to at least one dengue serotype, and 92.7% of the maternally transferred antibody had disappeared in 12-month-old infants. In all, 31 infants had serologically confirmed dengue infection; 5 symptomatic and 29 inapparent infections were reported. The increasing trend of inapparent infections among the older age group warrants further study of the need for effective dengue vaccination beyond 2 years of age.

Author Information

From the *Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; and †The Centre for Vaccine Development, Institute of Molecular Bioscience, Mahidol University, Thailand.

Accepted for publication April 11, 2011.

Supported by the Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University.

None of the authors have a commercial or other association that might pose a conflict of interest.

Address for correspondence: Krisana Pengsaa, MD, 420/6 Ratchawithi Rd, Ratchathewi, Bangkok 10400, Thailand. E-mail: tmkps@mahidol.ac.th.

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© 2011 Lippincott Williams & Wilkins, Inc.