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Comparison of Clinical and Biologic Features of Kingella kingae and Staphylococcus aureus Arthritis at Initial Evaluation

Basmaci, Romain MD*; Lorrot, Mathie MD, PhD*; Bidet, Philippe MD, PhD†; Doit, Catherine MPH†; Vitoux, Christine MD‡; Penneçot, Georges MD, PhD‡; Mazda, Keyvan MD, PhD‡; Bingen, Edouard MPH, PhD†; Ilharreborde, Brice MD, PhD‡; Bonacorsi, Stéphane MD, PhD†

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31821fe0f7
Brief Reports
Abstract

We conducted a retrospective study comparing the presenting clinical and biologic features of 64 children who had septic arthritis caused by Kingella kingae with 26 children who had septic arthritis caused by Staphylococcus aureus. Children with K. kingae septic arthritis were significantly younger than those with S. aureus septic arthritis. Otherwise, there were no significant differences between the 2 groups with respect to fever, location, white blood cell count, synovial fluid cell count, C-reactive protein, or serum fibrinogen. However, the clinical course was significantly better for children with septic arthritis caused by K. kingae as evidenced by shorter hospitalization and fewer adverse events. Presumptive antibiotic therapy for septic arthritis in young infants should take into account both of these pathogens, even in case of mild presentation.

Author Information

From the Departments of *Pediatrics, †Microbiology, and ‡Pediatric Orthopaedics, Hôpital Robert Debré, Assistance Publique Hôpitaux de Paris and Université Paris Diderot, Paris, France.

Accepted for publication April 14, 2011.

Brice Ilharreborde and Stéphane Bonacorsi contributed equally to this work.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Stéphane Bonacorsi, MD, PhD, Service de Microbiologie, Hôpital Robert-Debré, 48 Blvd Sérurier, 75395 Paris Cedex 19, France. E-mail: stephane.bonacorsi@rdb.aphp.fr.

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© 2011 Lippincott Williams & Wilkins, Inc.