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le Roux, David M. MB ChB, MPH, FCPaed*; Cotton, Mark F. MB ChB, FCPaed, PhD†; le Roux, Stanzi M. MB ChB*; Whitelaw, Andrew MB ChB, FCPath, MSc‡; Lombard, Carl J. PhD§; Zar, Heather J. MB ChB, PhD*
Bacteremia contributes to morbidity of HIV-infected children. In a randomized controlled trial evaluating trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis, 47 bacteremias were detected. The incidence rate of bacteremia increased in the first 3 months after starting combination antiretroviral therapy (cART), but decreased by 74% once children were established on cART for more than 3 months. Children should be prioritized for early cART.
© 2011 Lippincott Williams & Wilkins, Inc.
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Africa, children, HIV, bacteremia, antiretroviral therapy, trimethoprim-sulfamethoxazole, preventive therapy
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