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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31820fc8e1
Brief Reports

Single-dose Pharmacokinetics and Tolerability of Daptomycin 8 to 10 mg/kg in Children Aged 2 to 6 Years With Suspected or Proved Gram-positive Infections

Abdel-Rahman, Susan M. PharmD*; Chandorkar, Gurudatt PhD†; Akins, Ronda L. PharmD‡§; Bradley, John S. MD¶∥; Jacobs, Richard F. MD**; Donovan, Julie BA†; Benziger, David P. PhD†

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A pharmacokinetic analysis was performed for single intravenous doses of daptomycin 8 or 10 mg/kg in subjects aged 2 to 6 years. Proportional increases in maximum plasma concentration (68.4 μg/mL, 79.2 μg/mL) and area under the curve (429.1 μg · h/mL, 549.7 μg · h/mL) were observed for each dose cohort, respectively. Half-life, clearance, and distribution volume were similar between groups. Both doses were well tolerated.

© 2011 by Lippincott Williams & Wilkins, Inc.


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