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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3182138296
Brief Reports

Long-term Immunogenicity and Immune Memory After Two Doses of the Adult Formulation of a Combined Hepatitis A and B Vaccine in Children 1 to 11 Years of Age

van Damme, Pierre MD, PhD*; Kafeja, Froukje MD*; Van Der Wielen, Marie MD*; Leyssen, Maarten MD, PhD†; Jacquet, Jeanne-Marie PhD†

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Abstract

Long-term persistence of antibodies against hepatitis A and B (anti-HAV and anti-HBs) were evaluated in 1- to 11-year-old children following 2 doses (0, 6 months) of hepatitis A and B vaccine. Ten years postvaccination, all subjects were anti-HAV seropositive (≥15 mIU/mL), 81.7% had anti-HBs antibody concentrations ≥10 mIU/mL. All subjects with anti-HBs concentrations <10 mIU/mL, mounted a vigorous anamnestic response to an HBV vaccine challenge dose indicating the presence of immunologic memory against hepatitis B.

© 2011 by Lippincott Williams & Wilkins, Inc.

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