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No Efficacy of Prednisolone in Acute Wheezing Associated With Human Bocavirus Infection

Jartti, Tuomas MD*; Söderlund-Venermo, Maria PhD†; Allander, Tobias MD‡; Vuorinen, Tytti MD§; Hedman, Klaus MD†; Ruuskanen, Olli MD*

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318216dd81
Brief Reports
Abstract

The efficacy of prednisolone in acute wheezing associated with human bocavirus infection was investigated in 232 hospitalized children (median age, 1.6 years). Clinical history, atopy status, and viral etiology were carefully studied. Outcomes included hospitalization time, duration of symptoms, and occurrence of relapses. No efficacy of prednisolone was found in children with serologically confirmed acute human bocavirus infection.

Author Information

From the *Department of Pediatrics, Turku University Hospital, Turku, Finland; †Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland; ‡Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden; and §Department of Virology, University of Turku, Turku, Finland.

Accepted for publication October 28, 2010.

Supported by the Academy of Finland, the Finnish Cultural Foundation, the Turku University Foundation, the Foundation for Pediatric Research, and the Paulo Foundation.

Prednisolone and placebo were provided by Oy Leiras Finland Ab, Helsinki, Finland.

Address for correspondence: Tuomas Jartti, MD, Department of Pediatrics, Turku University Hospital, PO Box 52, FIN-20520 Turku, Finland. E-mail: tuomas.jartti@utu.fi.

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© 2011 Lippincott Williams & Wilkins, Inc.