Skip Navigation LinksHome > February 2011 - Volume 30 - Issue 2 > SEVERE PERTUSSIS IN INFANTS: ESTIMATED IMPACT OF FIRST VACCI...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181f43906
Brief Reports

SEVERE PERTUSSIS IN INFANTS: ESTIMATED IMPACT OF FIRST VACCINE DOSE AT 6 VERSUS 8 WEEKS IN AUSTRALIA

Foxwell, Alice Ruth MSc, PhD*†; McIntyre, Peter MB BS, PhD‡; Quinn, Helen MAE, PhD‡; Roper, Katrina MAE, PhD*; Clements, Mark S. PhD†

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Abstract

We estimated the potential benefits of advancing the first dose of pertussis vaccine for infants from 8 to 6 weeks of age, using Australian national disease databases. Infants had notification rates 3-fold greater than the general population and accounted for 52% of recorded hospitalizations. Infants 1 and 2 months of age had notification rates 3.5 times (95% CI: 2.7–4.5) higher than infants 3 to 11 months of age. Estimation of acceleration of the vaccine to 6 weeks of age reduced average notifications, hospitalizations, and hospital bed-days by 8%, 9%, and 12%, respectively, with larger reductions in an epidemic year.

© 2011 Lippincott Williams & Wilkins, Inc.

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