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PNEUMOCOCCAL MENINGITIS IN FRENCH CHILDREN BEFORE AND AFTER THE INTRODUCTION OF PNEUMOCOCCAL CONJUGATE VACCINE

Levy, Corinne MD*†; Varon, Emmanuelle MD*‡; Bingen, Edouard PhD*§; Lécuyer, Aurélie MD*†; Boucherat, Michel MD†; Cohen, Robert MD*†¶; The Bacterial Meningitis Study Group

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181f4cf69
Brief Reports
Abstract

In France, despite a high rate of pneumococcal conjugate vaccine coverage, the number of cases of pneumococcal meningitis in children did not decline significantly between 2001–2002 (n = 264) and 2007–2008 (n = 244). A decline was observed among children <2 years old (185 [70.1%] to 134 [54.9%] cases; P = 0.0004), but was counterbalanced by an increase among children ≥2 years old (79 [29.9%] to 110 [45.1%] cases). Mean age increased significantly, from 2.3 (median 0.8) to 3.8 (median 1.5) years. After pneumococcal conjugate vaccine 7 implementation, a wide diversity of serotypes implicated in pneumococcal meningitis was observed; serotypes 19A and 7F were the most frequent.

Author Information

From the *GPIP (Groupe de Pathologie Infectieuse Pédiatrique) de la SFP (Société Française de Pédiatrie), Paris, France; †ACTIV (Association Clinique et Thérapeutique Infantile du Val de Marne), Paris, France; ‡HEGP (Hôpital Européen Georges Pompidou), Centre National de Référence des Pneumocoques, Paris, France; §Service de Microbiologie, Hôpital Robert-Debré (AP-HP), Université Denis-Diderot, Paris 7, Paris, France; and ¶Centre Hospitalier Intercommunal de Créteil, Créteil, France.

Accepted for publication July 30, 2010.

Supported by the Pediatric Infectious Diseases Group of the French Pediatrics Society (GPIP) and Association Clinique et Therapeutique Infantile du Val de Marne (ACTIV).

The authors have no conflicts of interest to declare.

Address for correspondence: Corinne Levy, MD, ACTIV (Association Clinique et Thérapeutique Infantile du Val de Marne), 27 rue Inkermann, F94100 Saint Maur des Fossés, France. E-mail: activ@wanadoo.fr or activ@activfrance.fr.

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© 2011 Lippincott Williams & Wilkins, Inc.