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INCIDENCE OF INFLUENZA VIRUS INFECTION IN EARLY INFANCY: A PROSPECTIVE STUDY IN SOUTH ASIA

Henkle, Emily MPH, PhD*; Steinhoff, Mark C. MD*†; Omer, Saad B. MB BS, PhD‡; Roy, Eliza DCh§; Arifeen, Shams E. MB BS, DrPH§; Raqib, Rubhana PhD§; McNeal, Monica MS†; Breiman, Robert F. MD¶; Moss, William J. MD*; Zaman, K. MB BS, PhD§

Pediatric Infectious Disease Journal: February 2011 - Volume 30 - Issue 2 - pp 170-173
doi: 10.1097/INF.0b013e3181f63c39
Brief Reports

We evaluated infant sera from an immunization trial in Bangladesh to assess influenza hemagglutination inhibition antibody titer increases in 131 unimmunized infants from birth to 6 months. We detected 31 serologically defined infections. Combined with 10 additional rapid test-proven influenza cases, the minimal estimated incidence was 31 of 100 infants (95% CI: 24–41). These data suggest a high burden of influenza in young infants in tropical South Asia.

From the *Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD; †Global Health Center, Cincinnati Children's Hospital Medical Centre, Cincinnati, OH; ‡Global Health, Epidemiology, and Pediatrics, Rollins School of Public Health, Emory University, Atlanta, GA; §International Centre for Diarrheal Disease Research, Dhaka, Bangladesh; and ¶Centers for Disease Control and Prevention, Atlanta, GA.

Accepted for publication August 5, 2010.

The Mother's Gift project was supported by the Bill and Melinda Gates Foundation, United States Agency for International Development cooperative agreement HRN-A-0096–90006–00; Wyeth Pharmaceuticals Inc, the Thrasher Research Fund, Aventis Pasteur, ICDDR,B, and the Bloomberg School of Public Health at Johns Hopkins University. ICDDR,B, acknowledges with gratitude the commitment of donors to the Centre's research efforts. Ms. Henkle was supported by the Department of Health and Human Services, National Institutes of Health, National Eye Institute Training Grant Number EY 07127 Clinical Trials Training Program in Vision Research.

Research support from Merck, the Bill and Melinda Gates Foundation, and USAID (to R.F.B); research support from the Bill and Melinda Gates Foundation, USAID, the Thrasher Fund, Wyeth, Glaxo Smith-Kline, Sanofi-Aventis, and Merck, and lecture fees from GlaxoSmithKline and Sanofi-Aventis (to M.C.S.). No other potential conflict of interest relevant to this article was reported.

Registered with ClinicalTrials.gov: NCT 00142389.

Address for correspondence: Mark C. Steinhoff, MD, Children's Global Health Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 2048, Cincinnati, OH 45229–3039. E-mail: mark.steinhoff@cchmc.org.

© 2011 Lippincott Williams & Wilkins, Inc.