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STREPTOCOCCUS PNEUMONIAE NASOPHARYNGEAL COLONIZATION IN CHILDREN IN BRASOV, CENTRAL ROMANIA: HIGH ANTIBIOTIC RESISTANCE AND COVERAGE BY CONJUGATE VACCINES

Falup-Pecurariu, Oana MD*; Bleotu, Laura MD*; Zavarache, Cristina MD*; Peled, Nechama MSc†‡; Anton, Oana MD*; Robu, Michaela MD*; Falup-Pecurariu, Cristian MD*; Rogozea, Liliana MD*; Porat, Nurith MD‡§; Greenberg, David MD‡§; Dagan, Ron MD‡§; Leibovitz, Eugene MD‡§

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181f42bb6
Brief Reports
Abstract

We report high colonization rates among 400 healthy infants and children, and moderate (66%) coverage by PCV7 and PCV10, with a superior (80%) PCV13 coverage. Most frequent serotypes were 23F, 6B, 19F, and 14. Resistance to penicillin, ceftriaxone, erythromycin, and trimethoprim/sulfamethoxazole was 83%, 18%, 62%, and 66%, respectively. 67% isolates were multidrug resistant. Pneumococcal conjugate vaccines covered 80% to 93% of multidrug resistant isolates.

Author Information

From the *Department of Pediatrics, Children's Hospital, Faculty of Medicine, Transilvania University, Brasov, Romania; †Clinical Microbiology Laboratories, Soroka University Medical Center, Beer-Sheva, Israel; ‡Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; and §Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, Israel.

Accepted for publication July 20, 2010.

Supported by an ESPID Grant Award.

Address for correspondence: Eugene Leibovitz, MD, Pediatric Infectious Disease Unit, Soroka University Medical Center, PO Box 151, Beer-Sheva 84101, Israel. E-mail: eugenel@bgu.ac.il.

© 2011 Lippincott Williams & Wilkins, Inc.