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SUSTAINED PROTECTION FROM PENTAVALENT ROTAVIRUS VACCINATION DURING THE SECOND YEAR OF LIFE AT A LARGE, URBAN UNITED STATES PEDIATRIC HOSPITAL

Boom, Julie A. MD*†‡; Tate, Jacqueline E. PhD§; Sahni, Leila C. MPH*‡; Rench, Marcia A. BSN*†; Quaye, Osbourne PhD§; Mijatovic-Rustempasic, Slavica MSc§; Patel, Manish M. MD, MSc§; Baker, Carol J. MD*†¶; Parashar, Umesh D. MB BS, MPH§

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181ed18ab
Brief Reports
Abstract

Fecal specimens from children presenting to Texas Children's Hospital with acute gastroenteritis were tested for the presence of rotavirus. Children were grouped according to vaccination status, and pentavalent rotavirus vaccine effectiveness was calculated. Pentavalent rotavirus vaccine effectiveness against severe rotavirus gastroenteritis was sustained during the first 2 years of the vaccination program. Overall 3-dose effectiveness was 83% to 86%; it was 92% to 93% among children 6 to 11 months of age and 78% to 84% among children ≥12 months of age.

Author Information

From the *Center for Vaccine Awareness and Research, Texas Children's Hospital, Houston, TX; †Department of Pediatrics, Baylor College of Medicine, Houston, TX; ‡Immunization Project, Texas Children's Hospital, Houston, TX; §Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA; and ¶Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX.

Accepted for publication June 14, 2010.

Supported by a sole source grant from the Centers for Disease Control and Prevention and by in-kind contributions from Texas Children's Hospital.

The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention (CDC).

Address for correspondence: Julie A. Boom, MD, Center for Vaccine Awareness and Research, Texas Children's Hospital, 6701 Fannin St, CC1540, Houston, TX 77030. E-mail: jboom@bcm.edu.

© 2010 by Lippincott Williams & Wilkins, Inc.