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Substantial Morbidity for Hospitalized Children With Community-Acquired Rotavirus Infections: 20052007 IMPACT Surveillance in Canadian Hospitals

Le Saux, Nicole MD*; Bettinger, Julie A. PhD†; Halperin, Scott A. MD‡; Vaudry, Wendy MD§; Scheifele, David W. MD†; for Members of the Canadian Immunization Monitoring Program, Active (IMPACT)

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181e20c94
Brief Reports

We describe community-acquired rotavirus illness in 1359 children hospitalized at 12 centers in Canada between January 2005 and December 2007. The median age was 1.5 years. Almost half (48.6%) had significant dehydration, almost one-fifth (19%) had clinical sepsis and 7% had seizures at presentation. The median hospital stay was 3.4 days. Severe clinical presentations are less commonly described in surveillance programs.

Author Information

From the *Division of Infectious Diseases, CHEO Research Institute, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada; †Vaccine Evaluation Center, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada; ‡Canadian Center for Vaccinology, IWK Health Center and Dalhousie University, Halifax, Nova Scotia, Canada; and §Stollery Children's Hospital and University of Alberta, Edmonton, Alberta, Canada.

Accepted for publication March 25, 2010.

Supported by a grant from GlaxoSmithKline Inc, Merck Canada and the Public Health Agency of Canada's Centre for Food-borne, Environmental and Zoonotic Infectious Diseases and Centre for Immunization and Respiratory Infectious Diseases.

Presented at the International Congress of Chemotherapy and Infection; June 18-21, 2009; Toronto, Ontario, Canada.

Address for correspondence: Nicole Le Saux, MD, FRCP(C), Division of Infectious Diseases, Children's Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, ON K1S 3C4, Canada. E-mail:

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© 2010 Lippincott Williams & Wilkins, Inc.