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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181e284a6
Brief Reports

Lack of Increase in Vancomycin Resistance of Pediatric Methicillin-Resistant Staphylococcus aureus Isolates From 2000 to 2007

Zheng, Xiaotian MD, PhD*†; Qi, Chao PhD†‡; Arrieta, Mollyn BS*; O'Leary, Amanda BS*; Wang, Deli MD, PhD§¶; Shulman, Stanford T. MD∥**

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We retrospectively studied 306 pediatric methicillin-resistant Staphylococcus aureus isolates collected in 2000/2001, 2003, 2005, and 2007 for possible vancomycin minimum inhibitory concentration (MIC) change over time using Etest, agar dilution, and broth microdilution (MicroScan) methods. Vancomycin MICs did not increase. Inducible clindamycin resistance declined significantly (53%–0%, P < 0.001). Considerably different proportions of isolates with vancomycin MIC = 2 μg/mL were identified by different laboratory methodologies, suggesting the need for caution in their interpretation and in comparing published data. During this period the proportion of USA300 strains increased dramatically.

© 2010 Lippincott Williams & Wilkins, Inc.


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