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Lack of Increase in Vancomycin Resistance of Pediatric Methicillin-Resistant Staphylococcus aureus Isolates From 2000 to 2007

Zheng, Xiaotian MD, PhD*†; Qi, Chao PhD†‡; Arrieta, Mollyn BS*; O'Leary, Amanda BS*; Wang, Deli MD, PhD§¶; Shulman, Stanford T. MD∥**

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181e284a6
Brief Reports
Abstract

We retrospectively studied 306 pediatric methicillin-resistant Staphylococcus aureus isolates collected in 2000/2001, 2003, 2005, and 2007 for possible vancomycin minimum inhibitory concentration (MIC) change over time using Etest, agar dilution, and broth microdilution (MicroScan) methods. Vancomycin MICs did not increase. Inducible clindamycin resistance declined significantly (53%–0%, P < 0.001). Considerably different proportions of isolates with vancomycin MIC = 2 μg/mL were identified by different laboratory methodologies, suggesting the need for caution in their interpretation and in comparing published data. During this period the proportion of USA300 strains increased dramatically.

Author Information

From the *Department of Pathology and Laboratory Medicine, Children's Memorial Hospital, Chicago, IL; †Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Pathology and Laboratory Medicine, Northwestern Memorial Hospital, Chicago, IL; §Children's Memorial Research Center, Children's Memorial Hospital, Chicago, IL; ¶Department of Psychiatry and Behavior Science, Northwestern University Feinberg School of Medicine, Chicago, IL; ∥Division of Infectious Disease, Department of Pediatrics, Children's Memorial Hospital, Chicago, IL; and **Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL.

Accepted for publication March 25, 2010.

Address for correspondence: Xiaotian Zheng, MD, PhD, 2300 Children's Plaza, Box 53, Chicago, IL 60614. E-mail: x-zheng@northwestern.edu.

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© 2010 Lippincott Williams & Wilkins, Inc.