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PLACENTAL TESTING FOR TOXOPLASMA GONDII IS NOT USEFUL TO DIAGNOSE CONGENITAL TOXOPLASMOSIS

Filisetti, Denis MD, PhD; Cocquerelle, Vanessa; Pfaff, Alexander PhD; Villard, Odile MD, PhD; Candolfi, Ermanno MD, PhD

Pediatric Infectious Disease Journal: July 2010 - Volume 29 - Issue 7 - pp 665-667
doi: 10.1097/INF.0b013e3181d7a725
Brief Reports

We examined 785 placentas, including 51 from documented cases of congenital toxoplasmosis. Toxoplasma was detected in 16 placentas, including 1 in which congenital toxoplasmosis was ruled out. Placental screening had poor sensitivity (25%) but good specificity (99%), positive predictive value (93%), and negative predictive value (95%).

From the Institut de Parasitologie et de Pathologie Tropicale, les Hôpitaux Universitaires de Strasbourg et Université de Strasbourg, Strasbourg, France.

Accepted for publication February 2, 2010.

The authors D. F. and V. C. contributed equally to this work.

Address for correspondence: Denis Filisetti, MD, PhD, Laboratoire de Parasitologie et Mycologie Médicale, Les Hôpitaux Universitaires de Strasbourg, 3 rue Kœberlé, F-67000 Strasbourg, France. E-mail: denis.filisetti@unistra.fr.

© 2010 Lippincott Williams & Wilkins, Inc.