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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181d1de1d
Instructive Cases

Severe Epstein-Barr Virus Encephalitis With Hemophagocytic Syndrome: Rapid Clearance of Virus Following Allogeneic Hematopoietic Stem Cell Transplantation From a Seropositive Donor

Sovinz, Petra MD*; Schwinger, Wolfgang MD*; Lackner, Herwig MD*; Benesch, Martin MD*; Moser, Andrea MD*; Raicht, Andrea BSc*; Zobel, Gerfried MD†; Urban, Christian MD*

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Abstract

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with encephalitis is a life-threatening condition that requires treatment with immunochemotherapy; refractory patients are eligible for allogeneic hematopoietic stem cell transplantation. We report on an adolescent female who failed to respond to induction immunochemotherapy and was salvaged by allogeneic hematopoietic stem cell transplantation from her human leukocyte antigen-identical, Epstein-Barr virus-seropositive brother leading to rapid clearance of Epstein-Barr virus from blood and cerebrospinal fluid.

© 2010 Lippincott Williams & Wilkins, Inc.

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