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LONG-TERM IMMUNITY AFTER TWO DOSES OF INACTIVATED HEPATITIS A VACCINE, IN ARGENTINEAN CHILDREN

López, Eduardo L. MD*; Contrini, María M. MD*; Mistchenko, Alicia MD†; Debbag, Roberto MD‡

Pediatric Infectious Disease Journal: June 2010 - Volume 29 - Issue 6 - pp 568-570
doi: 10.1097/INF.0b013e3181d57a85
Brief Reports

We examined long-term anti-hepatitis A virus antibody persistence in Argentinean children 10 years after the initial study in which they received 2 doses of inactivated hepatitis A vaccine (Avaxim 80U). Of the 111 children, 48 from the initial trial were enrolled. Of 48, 47 (97.9%) participants had serum anti-hepatitis A virus antibody titers ≥20 mIU/mL, with the geometric mean concentration of 390.91 (±370.14) mIU/mL; (95% confidence interval, 282.2–499.5 mIU/mL), range, 36 to 1860.

From the *Infectious Diseases Program, Hospital de Niños “Dr. Ricardo Gutiérrez,” Buenos Aires, Argentina; †Laboratory of Virology, Hospital de Niños “Dr. Ricardo Gutiérrez,” Buenos Aires, Argentina; and ‡Sanofi Pasteur, Buenos Aires, Argentina.

Accepted for publication January 13, 2010.

Reprints: Eduardo L. López, MD, Guido 2676, Piso 10, 1425 Buenos Aires, Argentina. E-mail: eduardoluislopez@fibertel.com.ar.

© 2010 Lippincott Williams & Wilkins, Inc.