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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181cf8705
Original Studies

Hospitalizations for Kawasaki Syndrome Among Children in the United States, 1997–2007

Holman, Robert C. MS*; Belay, Ermias D. MD*; Christensen, Krista Y. MPH*; Folkema, Arianne M. MPH*; Steiner, Claudia A. MD, MPH†; Schonberger, Lawrence B. MD, MPH*

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Abstract

Background: The present study describes the rate and trends of childhood hospitalizations with Kawasaki syndrome (KS) in the United States.

Methods: Retrospective analysis of hospitalizations with KS among children <18 years of age in the United States using the Kids' Inpatient Database (1997, 2000, 2003, and 2006) and the Nationwide Inpatient Sample (1998–2007).

Results: The KS-associated hospitalization rate for children <5 years of age was 20.8 (95% CI: 18.5–23.1) per 100,000 children in 2006. Annual rates remained constant during the study period, except for a peak in 2005. In 2006, 76.8% (SE = 0.9%) of an estimated 5523 (SE = 289) KS-associated hospitalizations among children <18 years of age were <5 years of age. The mean age for all children at hospitalization was 3.0 years (SE <0.1); 25.7 months (SE = 0.3) for children <5 years of age, and 24.8 months (SE = 0.4) and 27.1 months (SE = 0.5) for boys and girls, respectively. The rate for boys was higher than that for girls (24.2 [95% CI: 21.3–27.1] and 16.8 [95% CI: 14.7–18.9], respectively). The rate for Asian/Pacific Islander children (30.3 [95% CI: 20.2–40.4]) was the highest among the racial groups.

Conclusions: The national KS-associated annual hospitalization rate for children <5 years of age from 1997 to 2007 was relatively stable and was similar to previously published rates, except for an increase in 2005. Most hospitalizations were in children <3 years of age with few hospitalizations during the first 2 months of age. Children of Asian/Pacific Islander descent had the highest hospitalization rate.

© 2010 Lippincott Williams & Wilkins, Inc.

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