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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181cfb65f
Brief Reports

HOSPITALIZATIONS FOR INVASIVE PNEUMOCOCCAL DISEASE AMONG HUMAN IMMUNODEFICIENCY VIRUS-1 INFECTED CHILDREN, ADOLESCENTS AND YOUNG ADULTS IN THE UNITED STATES IN THE ERA OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY AND THE CONJUGATE PNEUMOCOCCAL VACCINE

Kourtis, Athena P. MD, PhD*; Ellington, Sascha MSPH*; Bansil, Pooja MPH†; Jamieson, Denise J. MD, MPH*; Posner, Samuel F. PhD*

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Abstract

We describe hospitalization trends of invasive pneumococcal disease (IPD) among human immunodeficiency virus-infected individuals <25 years of age since the introduction of highly active antiretroviral therapy (HAART) and the 7-valent pneumococcal conjugate vaccine (PCV7) in the United States, using the Nationwide Inpatient Sample. We estimated national trends of IPD hospitalizations during 3 periods: 1994 to 1995 (pre-HAART and pre-PCV7 era); 1998 to 1999 (HAART and pre-PCV7 era); and 2004 to 2005 (HAART and early PCV7 era). The number of IPD hospitalizations among human immunodeficiency virus-infected children and youth <25 years in the United States declined by 78.7% between 1994/1995 and 2004/2005 (P = 0.03). This decrease was more pronounced among younger children.

© 2010 Lippincott Williams & Wilkins, Inc.

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