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HEPATITIS B VIRUS DNA IN SALIVA FROM CHILDREN WITH CHRONIC HEPATITIS B INFECTION: IMPLICATIONS FOR SALIVA AS A POTENTIAL MODE OF HORIZONTAL TRANSMISSION

Heiberg, Ida Louise MD*; Hoegh, Mette MSc, PhD; Ladelund, Steen MSc; Niesters, Hubert G. M. MD, DMSc§; Hogh, Birthe MD, DMSc*

The Pediatric Infectious Disease Journal: May 2010 - Volume 29 - Issue 5 - p 465-467
doi: 10.1097/INF.0b013e3181d8e009
Brief Reports

To explore the mechanism of horizontal transmission of hepatitis B virus (HBV) among children, we investigated the quantitative relationship between HBV in saliva and blood from 46 children with chronic hepatitis B.

We found high levels of HBV DNA in saliva of HBeAg (+) children, suggesting saliva as a vehicle for horizontal transmission of HBV among children.

From the *Department of Paediatrics, †Department of Clinical Microbiology, ‡Clinical Research Unit, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark; and §University Medical Center Groningen, Department of Medical Microbiology, Division of Clinical Virology, Groningen, The Netherlands.

Accepted for publication November 12, 2009.

Supported by Hvidovre Hospitals Research Foundation, the A.P. Moeller Foundation for the Advancement of Medical Science, Faculty of Health Sciences, University of Copenhagen, and Dagmar Marshall's Foundation.

Address for correspondence: Ida Louise Heiberg, MD, Department of Paediatrics 460, Hvidovre Hospital, University of Copenhagen, Kettegård Allé 30, 2650 Hvidovre, Denmark. E-mail: ida.heiberg@gmail.com.

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© 2010 Lippincott Williams & Wilkins, Inc.