Skip Navigation LinksHome > May 2010 - Volume 29 - Issue 5 > Characteristics of Children With Shigella Encephalopathy: Ex...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181cb4608
Original Studies

Characteristics of Children With Shigella Encephalopathy: Experience From a Large Urban Diarrhea Treatment Center in Bangladesh

Chisti, Mohammod Jobayer MB BS*; Faruque, Abu Syed Golam MPH*; Khan, Wasif Ali MD*; Das, Sumon Kumar MB BS*; Zabed, Mir Borhan MPharm†; Salam, Mohammed Abdus MB BS*

Press Release
Collapse Box

Abstract

Background: Encephalopathy is a serious neurologic complication from shigellosis often with fatal outcome but data on simple clinical and sociodemographic predicting factors are limited. We sought to identify those factors in children.

Methods: In this unmatched case-control design, children of both sexes, aged 0 to 15 years having positive stool culture for Shigella from 1997 to 2006 were studied. Children with Shigella encephalopathy constituted the cases (n = 29), whereas randomly selected children with shigellosis having no encephalopathy constituted controls (n = 87).

Results: The case-fatality was significantly higher among the cases than among controls (7% vs. 0%, RR: 4.2, CI: 3.0–5.9, P = 0.013). In logistic regression analysis, children with Shigella encephalopathy more often had an illiterate father (OR: 5.4, 95% CI: 1.1–27.1, P = 0.038), stopped breast-feeding in the neonatal period (OR: 41.3, 95% CI: 4.2–403.1, P = 0.001), had dehydrating diarrhea (OR: 9.9, 95% CI: 2.1–45.9, P = 0.004) with a duration of <1 day (OR: 29.4, 95% CI: 2.1–43.2, P = 0.004), and were more likely to be severely stunted (OR: 6.4, 95% CI: 1.2–34.9, P = 0.033).

Conclusion: Education of parents about the value of exclusive breast-feeding and of prompt hydration in children with Shigella is critical to minimize morbidity and deaths.

© 2010 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.