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Universal Mass Vaccination Against Rotavirus Gastroenteritis: Impact on Hospitalization Rates in Austrian Children

Paulke-Korinek, Maria MD, MSc*; Rendi-Wagner, Pamela MD, MSc, DTMH*†; Kundi, Michael MD‡; Kronik, Renate MD*; Kollaritsch, Herwig MD*

Pediatric Infectious Disease Journal: April 2010 - Volume 29 - Issue 4 - pp 319-323
doi: 10.1097/INF.0b013e3181c18434
Original Studies

Background: Since July 2007, rotavirus vaccinations have been subsidized in Austria for all children from the seventh week up to the sixth month of life. Vaccination coverage over the whole period was 72% with an increase to 87% in 2008.

Methods: In a sentinel network including 11 pediatric hospital wards in Austria, data of children up to 15 years of age and hospitalized due to rotavirus gastroenteritis between January 2001 and December 2008 have been collected.

Results: The hospitalization rates of children up to 12 months of age with rotavirus gastroenteritis were 2066 × 10−5 between 2001 and 2006 and decreased to 631 × 10−5 in 2008. For children between 12 and 24 months of age the hospitalization rate decreased from 1822 × 10−5 (2001–2006) to 1456 × 10−5 in 2008. In children aged 2 to less than 5 years, incidence rates were 436 ×10−5 (2001–2006) and 461 × 10−5 in 2008. In older children, the hospitalization rates remained unchanged. In the target population for the RV-vaccine, a decrease of hospitalization rates due to rotavirus gastroenteritis of 74% was observed compared to the era before the introduction of the vaccine. The field effectiveness of the vaccine was estimated between 61% and 98%, depending on assumptions about the vaccination status.

Conclusions: Within 18 months, the universal mass vaccination program against rotavirus led to a substantial decrease in the hospitalization rates of the target cohort of the immunization program in Austria.

From the *Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology, Pathophysiology and Immunology, Medical University Vienna, Vienna, Austria; †Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; and ‡Institute of Environmental Health, University Vienna, Vienna, Austria.

Accepted for publication September 19, 2009.

Supported by a grant of the Research Foundation of the Austrian National Bank (grant no. 6165).

Address for correspondence: Herwig Kollaritsch, MD, Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University Vienna, Kinderspitalgasse 15, A-1090 Vienna, Austria. E-mail: herwig.kollaritsch@meduniwien.ac.at.

© 2010 Lippincott Williams & Wilkins, Inc.