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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181c52a04
Brief Reports

Should Higher Vancomycin Trough Levels Be Targeted for Invasive Community-Acquired Methicillin-Resistant Staphylococcus Aureus Infections in Children?

Jimenez-Truque, Natalia MQC, MSCI; Thomsen, Isaac MD; Saye, Elizabeth BS; Creech, C. Buddy MD, MPH

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Abstract

Methicillin-resistant Staphylococcus aureus isolates with vancomycin minimal inhibitory concentrations (MICs) ≥1.5 μg/mL have been associated with poorer clinical outcomes and treatment failures in adults. We evaluated vancomycin MICs in 71 invasive pediatric community-acquired MRSA isolates from 2004 to 2008, using the E-test micromethod and the E-test macro-method. The modal MIC by micromethod was 1.5 μg/mL, and median vancomycin MICs did not increase over time.

© 2010 Lippincott Williams & Wilkins, Inc.

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