Skip Navigation LinksHome > April 2010 - Volume 29 - Issue 4 > SURVEILLANCE OF TRANSMITTED RESISTANCE TO ANTIRETROVIRAL DRU...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181c4dada
Brief Reports

SURVEILLANCE OF TRANSMITTED RESISTANCE TO ANTIRETROVIRAL DRUG CLASSES AMONG YOUNG CHILDREN IN THE WESTERN CAPE PROVINCE OF SOUTH AFRICA

van Zyl, Gert U. MD*; Cotton, Mark F. MD, PhD†; Claassen, Mathilda BSc(Hons)*; Abrahams, Charmaine RN*; Preiser, Wolfgang MD, PhD*

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Abstract

There are limited data on transmitted antiretroviral resistance in young children who require antiretroviral therapy. We adapted the World Health Organization surveillance strategy, testing antiretroviral naive infants (<18 months) in the Western Cape Province of South Africa, and detecting only 3 non-nucleoside reverse transcriptase inhibitors (NNRTI) and no NRTI or protease inhibitor surveillance mutations in 49 patients. The estimated NRTI and protease inhibitor transmitted antiretroviral resistance prevalence is low (<5%), predicting good therapeutic response in Western Cape infants.

© 2010 Lippincott Williams & Wilkins, Inc.

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