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HUMAN RHINOVIRUS CAUSES SEVERE INFECTION IN PRETERM INFANTS

van Piggelen, Renée O. MD*; van Loon, Anton M. PhD†; Krediet, Tanette G. MD, PhD*; Verboon-Maciolek, Malgorzata A. MD, PhD*

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181c6e60f
Brief Reports
Abstract

Data of 11 infants (median gestational age and birth weight 30 weeks and 1520 g, respectively) with severe human rhinovirus infection (HRV) are described. Nine of 11 (82%) were preterm infants and 7 of these 9 (78%) became infected during their stay in the neonatal intensive care unit. All infants presented with respiratory distress and all needed respiratory support for a median of 6 days. Radiologic findings included perihilar streakiness, atelectasis, focal consolidation, and hyperinflation. The diagnosis of HRV infection was made by real-time polymerase chain reaction in nasopharyngeal aspirate. All infants recovered from their HRV infection. HRV can cause severe disease in preterm infants requiring respiratory support.

Author Information

From the Departments of *Neonatology, and †Virology, University Medical Center, Utrecht, The Netherlands.

Accepted for publication October 20, 2009.

Address for correspondence: Malgorzata A. Verboon-Maciolek, MD, PhD, Department of Neonatology, University Medical Center, Lundlaan 6, 3584 EA Utrecht, KE 04.123.1, The Netherlands. E-mail: m.verboon-maciolek@umcutrecht.nl.

© 2010 Lippincott Williams & Wilkins, Inc.