Skip Navigation LinksHome > January 2010 - Volume 29 - Issue 1 > Nosocomial Rotavirus Gastroenteritis in Spain: A Multicenter...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181b3603a
Original Studies

Nosocomial Rotavirus Gastroenteritis in Spain: A Multicenter Prospective Study

Gutiérrez-Gimeno, M Victoria BSc, PhD*; Martin-Moreno, Jose M. MD, PhD*; Díez-Domingo, Javier MD, PhD†; Asensi-Botet, Francesc MD, PhD‡; Hernández-Marco, Roberto MD, PhD§; Correcher-Medina, Patricia MD¶; Sánchez-Fauquier, Alicia MD, PhD∥

Collapse Box


Background: The objective of this study was to assess the incidence of nosocomial rotavirus gastroenteritis among children <2 years of age.

Methods: We conducted a prospective active surveillance for acute gastroenteritis (AGE) in the pediatric wards of 3 representative hospitals in Valencia (Spain) from October 2006 to March 2007, among children between 1 and 23 months of age with acute diarrhea. Children were followed up for 3 days after discharge. We obtained clinical and demographic information from participants and tested their stool specimens for rotavirus.

Results: A total of 1576 children were hospitalized at the 3 hospitals and 1300 (82.5%) were followed up as the study cohort. In 69 children, AGE started 48 hours after admission and were considered nosocomial infections. In 35 of the 59 cases where stool samples were obtained, rotavirus (RV) was present (59%), and in 12 of them symptoms started after discharge. The accumulated incidence of nosocomial rotavirus disease during the study period was 2.8 cases per 100 inpatients (95% CI: 1.9–3.8), and the incidence rate was 4.8 cases per 1000 hospital days (95% CI: 3.2–6.5). The most commonly found genotype in nosocomial infection was G9P[8], in 23 cases (66%), followed by G1P[8] in 4 cases (11%). The total economic cost was €883 per case.

Conclusion: Active surveillance demonstrated that the burden of nosocomial rotavirus disease is substantial, and G9P [8] was the genotype found most frequently. Following up children after discharge from hospital allowed the discovery of cases of nosocomial RVAGE which are missed in most other studies.

© 2010 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.