Itraconazole Treatment of Nonmeningeal Coccidioidomycosis in Children: Two Case Reports and Review of the LiteratureHomans, James D. MD, MPH; Spencer, LaShonda MDPediatric Infectious Disease Journal: January 2010 - Volume 29 - Issue 1 - pp 65-67 doi: 10.1097/INF.0b013e3181b20ebd Instructive Cases Abstract Author Information Coccidioides immitis causes a wide range of disease in humans. Fluconazole and itraconazole are effective treatments. Clinical evidence suggests that itraconazole is equivalent or superior to fluconazole in treating osteoarticular infections in rates of cure and recurrence. We report 2 cases of coccidioidomycosis involving bone in children successfully treated with itraconazole oral solution. Itraconazole oral solution is effective in treating nonmeningeal coccidioidomycosis in children, particularly skeletal disease, and infections that are refractory to fluconazole. From the Division of Infectious Diseases, Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, CA. Accepted for publication June 9, 2009. Address for correspondence: James D. Homans, MD, MPH, Division of Infectious Diseases, Department of Pediatrics, University of Southern California School of Medicine, 1640 Marengo St 3rd floor, Los Angeles, CA 90033. E-mail: firstname.lastname@example.org. © 2010 Lippincott Williams & Wilkins, Inc.