Eastern equine encephalitis virus infection is a rare sporadic central nervous system infection transmitted by a mosquito vector. Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease associated with the inability of an overactive immune system to effectively respond to infections. Many viruses are known to trigger primary, as well as secondary, HLH. We report a pediatric case of eastern equine encephalitis virus-associated HLH which caused severe neurologic injury and death.
From the Departments of *Pediatrics, †Radiology, and ‡Pathology, University of South Alabama College of Medicine, Mobile, AL.
Accepted for publication November 13, 2008.
Address for Correspondence: Mary Y. Mancao, MD, Division of Infectious Diseases, Department of Pediatrics, University of South Alabama, 1504 Springhill Avenue, Room 5224 Mobile, AL 36604. E-mail: firstname.lastname@example.org.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.pidj.com).