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EASTERN EQUINE ENCEPHALITIS VIRUS INFECTION AND HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN A 5-MONTH-OLD INFANT

Mancao, Mary Y. MD*; Imran, Hamayun MD*; Chandra, Sharat MD*; Estrada, Benjamin MD*; Figarola, Maria MD†; Sosnowski, Jeffrey MD‡; Vidal, Rosa MD*

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181950e99
Brief Reports
Abstract

Eastern equine encephalitis virus infection is a rare sporadic central nervous system infection transmitted by a mosquito vector. Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease associated with the inability of an overactive immune system to effectively respond to infections. Many viruses are known to trigger primary, as well as secondary, HLH. We report a pediatric case of eastern equine encephalitis virus-associated HLH which caused severe neurologic injury and death.

Author Information

From the Departments of *Pediatrics, †Radiology, and ‡Pathology, University of South Alabama College of Medicine, Mobile, AL.

Accepted for publication November 13, 2008.

Address for Correspondence: Mary Y. Mancao, MD, Division of Infectious Diseases, Department of Pediatrics, University of South Alabama, 1504 Springhill Avenue, Room 5224 Mobile, AL 36604. E-mail: mmancao@usouthal.edu.

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© 2009 Lippincott Williams & Wilkins, Inc.