An increase in the incidence of Group A streptococcal necrotizing fasciitis has recently been observed in Montréal, Canada. Clinical features of children hospitalized for invasive Group A streptococcal infections and various virulence factor genes of the bacteria were concomitantly analyzed. It was determined that varicella and presence of speC gene in group A streptococcal strains were associated with necrotizing fasciitis.
From the *Infectious Diseases Division, Department of Pediatrics, CHU Sainte-Justine, Montréal, Canada; †Pediatric Emergency, CHU Nord, Chemin des Bourrelly, 13015 Marseille, France; ‡Department of Microbiology, Robert Debré Hospital, Paris, France; and §Department of Microbiology and Immunology, CHU Sainte-Justine, Montréal, Canada.
Accepted for publication November 18, 2008.
Supported by the Association pour le Développement de la Recherche Médicale (ADEREM), Marseille, France (to P.M.).
Address for correspondence: Philippe Ovetchkine, MD, Infectious Diseases Division, Department of Pediatrics, CHU Sainte-Justine-Université de Montréal, 3175 Côte Sainte-Catherine, Montréal (Qc), Canada H3T 1C5. E-mail: firstname.lastname@example.org.