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DAPTOMYCIN THERAPY FAILURE IN AN ADOLESCENT WITH METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS BACTEREMIA

Jacobson, Lara M. MD*; Milstone, Aaron M. MD†; Zenilman, Jonathan MD‡; Carroll, Karen C. MD§; Arav-Boger, Ravit MD†

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181927891
Brief Reports
Abstract

Daptomycin is a Food and Drug Administration-approved alternative to vancomycin for the treatment of serious methicillin-resistant Staphylococcus aureus infections in adults. Treatment failure with daptomycin is increasingly reported in adults, but data in children are limited. We report an adolescent patient with severe burn injuries who had persistent methicillin-resistant Staphylococcus aureus bacteremia and rapidly developed nonsusceptibility to daptomycin. We review the relevant literature.

Author Information

From the *Department of Pediatrics and †Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD; ‡Infectious Diseases Division, Johns Hopkins Bayview Medical Center, Baltimore, MD; and §Division of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, MD.

Accepted for publication October 23, 2008.

Address for correspondence: Lara Jacobson, MD, Department of Pediatrics, CMSC 2-124, 600 N. Wolfe St., Baltimore, MD 21287-3224. E-mail: ljacob19@jhmi.edu.

© 2009 Lippincott Williams & Wilkins, Inc.