Skip Navigation LinksHome > March 2009 - Volume 28 - Issue 3 > Pertussis Vaccine: A Critique
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31818a8958
Opinion and Analysis

Pertussis Vaccine: A Critique

Robbins, John B. MD‡; Schneerson, Rachel MD‡; Keith, Jerry M. PhD‡; Miller, Mark A. MD*; Kubler-Kielb, Joanna PhD‡; Trollfors, Birger MD†

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Abstract

A critical level of serum IgG pertussis toxin antibody is both essential and sufficient to confer individual and herd immunity to pertussis. Monocomponent pertussis toxoid conferred such immunity in Sweden and in Denmark. We refute the notion that filamentous hemagglutinin, pertactin, and fimbriae add to the immunity conferred by pertussis toxoid and describe the artifact created when efficacy is estimated for multicomponent pertussis vaccines. Lastly, the genetically-inactivated mutant pertussis toxoid is safer, more immunogenic, and should be more effective than the current chemically-inactivated pertussis toxin.

© 2009 Lippincott Williams & Wilkins, Inc.

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