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PERTUSSIS OUTBREAK IN PRIMARY AND SECONDARY SCHOOLS IN LUDWIGSLUST, GERMANY DEMONSTRATING THE ROLE OF WANING IMMUNITY

Sin, Muna Abu MD*; Zenke, Rosemarie MD†; Rönckendorf, Rita†; Littmann, Martina MD‡; Jorgensen, Pernille MSc§; Hellenbrand, Wiebke MD¶

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31818a5d69
Brief Reports
Abstract

A pertussis outbreak primarily affecting school-age children in Ludwigslust, Germany, was investigated in 2006 to estimate attack rates and relative risk of pertussis according to time since last vaccination, after a complete primary course. Results suggested waning immunity beginning ∼5 years after the last dose of pertussis vaccination. Most cases could have been prevented by earlier booster vaccination.

Author Information

From the *Field Epidemiology Training Program, Robert Koch Institute, Berlin, Germany; †Local Health Authorities, Ludwigslust, Mecklenburg-Western Pomerania, Germany; ‡Regional Health Authority, Rostock, Mecklenburg-Western Pomerania, Pomerania, Germany; §European Programme for Intervention Epidemiology Training, Robert Koch Institute, Berlin, Germany; and ¶Robert Koch Institute, Berlin, Germany.

Accepted for publication August 13, 2008.

Address for correspondence: Wiebke Hellenbrand, MD, Department of Infectious Diseases Epidemiology, Seestrasse 10, D-13353 Berlin, Germany. E-mail: HellenbrandW@rki.de.

© 2009 Lippincott Williams & Wilkins, Inc.