The increased incidence of methicillin-resistant Staphyloccocus aureus infections may increase linezolid use in children. Peripheral neuropathy is a rare adverse effect of linezolid therapy and is more frequent with prolonged courses. We present an adolescent with peripheral neuropathy after 4 months of linezolid therapy and review the literature related to linezolid-induced neuropathies. Children receiving long-term linezolid therapy should be monitored for neuropathy.
From the Divisions of *Pediatric Infectious Diseases, †Healthcare Quality and Clinical Effectiveness, and ‡Pediatric Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Accepted for publication November 7, 2008.
Address for correspondence: W. Matthew Linam, MD, Division of Pediatric Infectious Diseases, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5019, Cincinnati, OH 45229-3039. E-mail: firstname.lastname@example.org.