Skip Navigation LinksHome > February 2009 - Volume 28 - Issue 2 > MULTIPLE RELAPSES OF VISCERAL LEISHMANIASIS IN AN ADOLESCENT...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318185513d
Brief Reports

MULTIPLE RELAPSES OF VISCERAL LEISHMANIASIS IN AN ADOLESCENT WITH IDIOPATHIC CD4+ LYMPHOCYTOPENIA ASSOCIATED WITH NOVEL IMMUNOPHENOTYPIC AND MOLECULAR FEATURES

Prigione, Ignazia PhD*; Castagnola, Elio MD†; Imberti, Luisa MD‡; Gambini, Claudio MD§; Gradoni, Luigi PhD¶; Dianzani, Umberto MD∥; Ramenghi, Ugo MD**; Giacopelli, Francesca PhD††; Moretta, Alessandro MD‡‡; Moretta, Lorenzo MD§§; Plebani, Alessandro MD¶¶; Fischer, Alain MD∥∥; Pistoia, Vito MD*

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Abstract

An adolescent with idiopathic CD4+ lymphocytopenia suffered from 4 visceral leishmaniasis relapses despite appropriate treatment. CD8 lymphocytopenia and abnormal expansion of TCRαβ+, CD4, CD8 cells were consistently detected together with reduced export of mature T cells from thymus. This novel form of idiopathic CD4+ lymphocytopenia may predispose to multiple visceral leishmaniasis relapses.

© 2009 Lippincott Williams & Wilkins, Inc.

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