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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31818b0c9c
Antimicrobials in Perspective

Ciprofloxacin 0.3%/Dexamethasone 0.1% Sterile Otic Suspension for the Topical Treatment of Ear Infections: A Review of the Literature

Wall, G Michael PhD*; Stroman, David W. PhD*; Roland, Peter S. MD†; Dohar, Joseph MD‡

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Abstract

The objective of this article is to review the literature related to ciprofloxacin 0.3% and dexamethasone 0.1% sterile otic suspension. A systematic literature search utilizing Medline was conducted to identify peer-reviewed articles related to safety and efficacy. A total of 47 publications were identified and reviewed herein. The literature supports the use of antibiotic/antiiflammatory combination ear drops in the treatment of both acute otitis externa and acute otitis media in pediatric patients with tympanostomy tubes. Ciprofloxacin/dexamethasone has been demonstrated as safe and effective with regard to clinical cures and microbiological eradication of pathogens in either disease with low treatment failure rates. Additionally, the literature also provides clear evidence for the contribution of dexamethasone when added to ciprofloxacin for the topical treatment of ear infections.

© 2009 Lippincott Williams & Wilkins, Inc.

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