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Ciprofloxacin 0.3%/Dexamethasone 0.1% Sterile Otic Suspension for the Topical Treatment of Ear Infections: A Review of the Literature

Wall, G Michael PhD*; Stroman, David W. PhD*; Roland, Peter S. MD†; Dohar, Joseph MD‡

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31818b0c9c
Antimicrobials in Perspective
Abstract

The objective of this article is to review the literature related to ciprofloxacin 0.3% and dexamethasone 0.1% sterile otic suspension. A systematic literature search utilizing Medline was conducted to identify peer-reviewed articles related to safety and efficacy. A total of 47 publications were identified and reviewed herein. The literature supports the use of antibiotic/antiiflammatory combination ear drops in the treatment of both acute otitis externa and acute otitis media in pediatric patients with tympanostomy tubes. Ciprofloxacin/dexamethasone has been demonstrated as safe and effective with regard to clinical cures and microbiological eradication of pathogens in either disease with low treatment failure rates. Additionally, the literature also provides clear evidence for the contribution of dexamethasone when added to ciprofloxacin for the topical treatment of ear infections.

Author Information

From the *Alcon Research Ltd, Fort Worth, TX; †Department of Otolaryngology, University of Texas Southwestern Medical School, Dallas, TX; and ‡Department of Otolaryngology, Children's Hospital of Pittsburgh, Pittsburgh, PA.

Accepted for publication August 14, 2008.

Drs. Wall and Stroman are Alcon employees and stockholders. Drs. Roland and Dohar are consultants for Alcon.

Address for correspondence: Julie Crider, PhD, Alcon Laboratories, Inc. (TA6-2), 6201 South Freeway, Fort Worth, TX 76134-2099. E-mail: Julie.Crider@AlconLabs.com.

© 2009 Lippincott Williams & Wilkins, Inc.