We report a tuberculosis outbreak in school children caused by exposure to a sputum-smear positive school bus driver. Exposed children were assessed using 2 versions of interferon-gamma release assays. Fifty-five percent (18/34) had a positive interferon-gamma release assays and 4 children developed tuberculosis. This suggests that transmission may be very efficient in this setting and highlights the need for early diagnosis.
From the *Hampshire and Isle of Wight Health Protection Agency, †Portsmouth Hospitals NHS Trust, ‡Portsmouth City Primary Care Trust, Portsmouth PO3 6DP, Hampshire, and §Tuberculosis Section, Centre for Infection, Health Protection Agency, Colindale, London, U.K.
Accepted for publication February 22, 2008.
The funding sources had no role in study design, conduct, reporting, or the decision to submit the paper for publication.
Address for correspondence: Dr Edmundo Neira Munoz, Consultant Physician in Health Protection, Hampshire and Isle of Wight Health Protection Unit, Finchdean House, Milton Road, Portsmouth PO3 6DP, Hampshire, U.K. E-mail: firstname.lastname@example.org.