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CONGENITAL CYTOMEGALOVIRUS INFECTION IN A HIGHLY SEROPOSITIVE SEMI-URBAN POPULATION IN INDIA

Dar, Lalit MD*; Pati, Sunil Kumar MSc*; Patro, A Raj Kumar MSc*; Deorari, Ashok Kumar MD†; Rai, Sanjay MD‡; Kant, Shashi MD‡; Broor, Shobha MD*; Fowler, Karen B. DrPH§; Britt, William J. MD§¶; Boppana, Suresh B. MD§¶

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3181723d55
Brief Reports
Abstract

To determine the incidence and natural history of congenital cytomegalovirus (CMV) infection in a population of women with near universal serologic reactivity for CMV, a prospective study of 423 women attending the antenatal clinic of the Comprehensive Rural Health Center in northern India was conducted. All 9 (2.1%) CMV positive infants were born to mothers who were CMV seropositive at the first antenatal visit. One child had hepatosplenomegaly at birth and another child had mild unilateral hearing loss at 4 months of age.

Author Information

From the *Departments of Microbiology, †Pediatrics, and ‡Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India; and Departments of §Pediatrics, ∥Epidemiology, and ¶Microbiology, University of Alabama at Birmingham, Birmingham, AL.

Accepted for publication March 3, 2008.

Supported by research grants from the Indian Council of Medical Research, the Indo-U.S. Maternal Child Health Development Research (3R01 DC04163-S2), and the National Institute on Deafness and Other Communication Disorders (3R01 DC04163).

Address for correspondence: Suresh B. Boppana, MD, Department of Pediatrics, University of Alabama at Birmingham, CHB 114, 1600 7th Ave. South, Birmingham, AL 35233. E-mail: sboppana@peds.uab.edu.

© 2008 Lippincott Williams & Wilkins, Inc.