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Treatment of Central Venous Catheter Fungal Infection Using Liposomal Amphotericin-B Lock Therapy

Buckler, Bradley S. MD*; Sams, Ralph N. BS†; Goei, Vita L. MD*; Krishnan, Karthik R. MD*; Bemis, Marci J. PharmD‡; Parker, Deidrea P. RPh‡; Murray, Dennis L. MD*

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318170b68b
Brief Reports

The current standard of care for a fungal central venous catheter infection in a pediatric patient usually requires removal without any other feasible options. Although removal may reduce the rate of Candida-associated complications, literature reviews question whether the outcomes of removal substantiate this being the standard of care. We report 6 cases of central venous catheter fungal infections treated with liposomal amphotericin-B lock therapy. These cases consisted of 4 patients, 2 of whom received recurrent therapy. In 4 of these cases, there was successful eradication of the infectious fungal agent, allowing continued use of the catheter. A controlled study of antifungal lock therapy should be considered as a potential alternative to removal.

Author Information

From the *Department of Pediatrics, †Medical College of Georgia School of Medicine, and ‡Department of Pharmacy, Medical College of Georgia, Augusta, GA.

Accepted for publication February 26, 2008.

Address for correspondence: Brad Buckler, MD, 1120 15th Street, Augusta, GA 30912. E-mail:

© 2008 Lippincott Williams & Wilkins, Inc.